Similar postprandial VLDL-TG metabolism in men with and without T2D

Similar postprandial VLDL-TG metabolism in men with and without T2D -
10.10.17

A new study, published in Journal of Metabolism: Clinical and Experimental (October 2017) by Danish Diabetes Academy Post Doc Esben Søndergaard, shows similar postprandial VLDL-TG metabolism in men with and without type 2 diabetes.

SIMILAR POSTPRANDIAL SUPPRESSION OF VLDL-TG SECRETION

Men with type 2 diabetes have similar postprandial suppression of VLDL-TG secretion. Therefore, the abnormalities in postprandial VLDL-TG metabolism is a consequence of obesity/insulin resistance and not type 2 diabetes in itself. Instead, the excessive postprandial lipemia in type 2 diabetes is a consequence of more plasma chylomicrons instead of VLDL particles, most likely due to increased chylomicron appearance from enterocytes.

SIMILAR VLDL-TG STORAGE IN ADIPOSE TISSUE

A reduced capacity to store excess calories in adipose tissue lipid may lead to ectopic fat storage, causing insulin resistance and type 2 diabetes. However, in this study, there was no difference in the ability to VLDL-TG after a high fat meal despite excess postprandial lipemia.

AUTHORS AND AFFILIATIONS 

Søndergaard E1, Johansen RF2, Jensen MD3, Nielsen S2.

1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark; Danish Diabetes Academy, Odense University Hospital, Kløvervænget 10, Entrance 112, 3rd floor, 5000 Odense C, Denmark; Endocrine Research Unit, Mayo Clinic, 1216 2nd St SW, Rochester, MN 55902, USA
2Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
3Endocrine Research Unit, Mayo Clinic, 1216 2nd St SW, Rochester, MN 55902, USA

Source: Journal of Metabolism: Clinical and Experimental