Sphingolipid metabolism in type 1 diabetes: Type 1 diabetes is a massive problem around the world with an estimate increase of 3% per year in Denmark. Type 1 diabetes is caused by dysfunctional beta cells leading to an autoimmune reaction resulting in the destruction of the insulin producing beta cells. We have recently described how sphingolipids, a diverse group of lipids found in all cellular membranes, are dysregulated at the onset of type 1 diabetes (Holm et al. 2018, Diabetologia). We have furthermore showed that we by modulating sphingolipid metabolism are able to prevent diabetes in a mouse model. We wish to further study the mechanism behind the role of sphingolipids in type 1 diabetes pathology. To achieve this the candidate will use develop strategies to evaluate and modulate sphingolipid metabolism during diabetes development and test these using cell cultures and animal models. Changes in sphingolipid metabolism will be evaluate using a variety of molecular methods coupled with a mass spec lipidomic approach in association with our collaborators.
We look for a highly motivated person with a background in ideally molecular biology or biochemistry. The candidate will join the Bartholin institute lead by professor Karsten Buschard. The Bartholin institute is a research group at Rigshospitalet in the department of Rigshospitalet. The Position is for 3 years and the candidate will be enrolled as a PhD student at the Faculty of Health and Medical Sciences at the University of Copenhagen.