On Thursday 14 June 2018 at 2:00 PM, Danish Diabetes Academy PhD fellow Eva Pers Winning Jepsen will defend her PhD thesis entitled 'Mechanisms of weight loss and weight loss maintenance associated with GLP-1 and GLP-1 receptor agonists' in the Maersk Tower, Copenhagen. All interested are welcome to attend the public PhD defense.
TIME & PLACE OF DEFENCE
14 June 2018, 2:00-5:00 PM
Mærsk Tower, Holst Auditorium
Nørre Allé 6
DK-2200 Copenhagen N
- Associate Professor Signe Sørensen Torekov
- Professor Jens Juul Holst
- Professor Birgitte Holst (Chairperson)
- Professor Jens Meldgaard Bruun
- Professor Nick Finer
MAIN RESULTS OF THE PHD THESIS
The thesis covers aspects of the dysregulation of the gut hormone profile in obesity and its restoration with weight loss (study 1) as well as mechanisms for liraglutide-induced satiety (study 2) and bone preservation (study 3).
In study 1 we show that obese individuals are characterized by low circulating levels of GLP-1 and PYY, and that weight reduction normalized (i.e. increase) these levels. Furthermore, the restoration of the gut-hormones was preserved after 1 year of weight maintenance, suggestive of a permanent restoration in response to maintained weight loss.
In study 2 we explored the importance of the hypothalamic melanocortin pathway in GLP-1RA mediated satiety. By administering liraglutide for 16 weeks to heterozygous carriers of a MC4R mutation, and comparing the response to that in obese non-mutation carriers, we saw that the two groups responded identically to the treatment, suggesting that the central melanocortin system is not of key importance in GLP-1 RA mediated appetite inhibition.
Finally, in study 3 we explored the impact of the GLP-1RA, liraglutide, on bone metabolism in obese weight-reduced women. We found that liraglutide treated women lost less bone mass evaluated by bone mineral content (BMC) than the control group and displayed an increase in the bone formation marker P1NP compared to the control group.
HOW TO FIND THE HOLST AUDITORIUM
Enter the Maersk Tower by the main entrance from Blegdamsvej or use the other entrance from Nørre Allé (see map below)
From the main entrance, walk up the big staircase and turn right. Follow signs to Holst Auditorium.