The Epigenetics and Diabetes Unit at Lund University Diabetes Center is seeking a postdoctoral research fellow with application deadline August 28, 2017. The Epigenetics and Diabetes Unit investigates the role of epigenetic modifications in cellular development and function in tissues of importance for type 2 diabetes (T2D); pancreatic islets, adipose tissue, muscle and liver. Our goal is to deepen our basic understanding of epigenetics and T2D and to identify therapeutic targets for new treatments of the disease.
The successful applicant will make use of data from global epigenetic studies in human cohorts and other large-scale analyses, including mRNA expression and human genome-wide association studies. The applicant will further perform in vitro and/or in vivo experiments on selected candidate genes from these data sets to validate their importance for cellular function and T2D. The position may also give the possibility to supervise undergraduate and graduate students. The work will be performed in close collaboration with both other experimental researchers and bioinformaticians. The position will be funded for two years by a postdoctoral stipend, with possible extension for one year or more conditioned on performance and funding.
ABOUT THE EPIGENETICS AND DIABETES UNIT AT LUND UNIVERSITY
Over the last decade the Epigenetics and Diabetes Unit has pioneered the field of T2D epigenetics, resulting in papers in high impact journals such as Nature Communications, JCI, PNAS and PLoS Genetics.
The group is part of Lund University Diabetes Centre (LUDC, http://www.ludc.lu.se/) - a world leading consortium of research groups at Lund University dedicated to unravelling the pathogenesis of diabetes mellitus. LUDC offers a unique environment with researchers from many different fields and it is well equipped for epigenetic research with a Mass Array system from Sequenom as well as a Genome Analyser and Infinium system from Illumina. LUDC also have unique human clinical cohorts.
The candidate should be self-motivated and able to work independently, in addition to fulfilling the following:
- Being close to completing their PhD or having obtained their PhD within the last three years.
- Research experience in cell and molecular biology, or a related field.
- Strong scientific integrity and ethics.
- Proven track record of research (e.g. publication record).
- Ability to prioritise and manage own time, multi-task and integrate the demands of different activities in parallel.
- Strong written and oral communication skills (English).
- A deep knowledge of epigenetics and/or diabetes research
- A deep knowledge of pancreatic islet, muscle, liver or adipose tissue biology
- Experience of some or all of the following: genetic manipulation of cultured cells (siRNA/plasmid transfection, viral transduction, CRISPR/Cas9), common molecular biology methods (PCR/qPCR, western blot, ELISA, etc), working with rodent in vivo models (experience of animal work in relation to metabolic/T2D research, such as glucose tolerance tests, will give extra merit), studies of cellular metabolism (fuel oxidation, mitochondrial respiration, ATP production, etc).
HOW TO APPLY
Interested applicants should send a cover letter, full curriculum vitae, publication list, contact details of two referees, and a short statement describing their research interests and future goals to firstname.lastname@example.org
For further information please contact Dr Charlotte Ling:
Phone: +46 4039 1213